Sequence information
DRAVP ID DRAVPc052
Name Angiotensin (1-7)(TXA127)
Sequence
Molecular Formula C41H62N12O11
Condition/Disease COVID-19
Group Phase Ⅱ clinical trial
Type Peptide
Description Therapeutic Angiotensin-(1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. In the renin-angiotensin system, the vasodilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II.
Active sequence/Structure
Comment
No comments found
External Links
DrugBank Accession Number DB11720
Pubchem ID 123805
CHEMBL ID CHEMBL3545347
UNII IJ3FUK8MOF
CAS 51833-78-4
ClinicalTrails Information
| NCT Number | Study Title | Condition/Disease | Status | Phase | Sponsor |
|---|---|---|---|---|---|
| NCT04401423 | TXA127 for the Treatment of Severe COVID-19 | COVID-19 | Completed | Phase 2 | Columbia University |
| NCT04605887 | Angiotensin 1-7 as a Therapy in the Treatment of COVID-19 | COVID-19 | Recruiting | Phase 2 | Rambam Health Care Campus |
