General Information
DRAVP ID DRAVPe00027
Peptide Name NL9-C2A
Sequence AAWWAGIKQEF
Sequence Length 11
UniProt ID No entry found
Taxon ID
Source Synthetic construct(derived from HIV-1 integrase)
Validation
Origin Information
Gene Name/ID
GenBank
Amino Acid position
Domain Accession ID
Nucleotide sequence ID
Molecular Type
Chromosomal Position
Activity Information
Target Organism HIV
Assay Integrase Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism HIV-1 integrase (IN) is essential for viral replication. Following reverse transcription of the RNA into DNA by HIV-1 reverse transcriptase, IN integrates the viral DNA into the host genome.The peptide could inbibit integrase(By inhibiting the two steps of IN catalysis: 3′-processing and strand transfer).
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00027
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C64H87N15O15
Absent amino acids CDHLMNPRSTVY
Common amino acids A
Mass 1306.49
Pl 6.05
Basic residues 1
Acidic residues 1
Hydrophobic residues 7
Net charge 0
Boman Index 103
Hydrophobicity -3.64
Aliphatic Index 62.73
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 1100
Polar residues 1
Literature Information
Literature 1
Title Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.
Pubmed ID 16854053
Reference J Med Chem. 2006 Jul 27;49(15):4477-86.
Author Li HY, Zawahir Z, Song LD, Long YQ, Neamati N.