DRAVP ID  DRAVPe00036

Peptide Name   NL6-1

Sequence  TASFLLKLAGRW

Sequence Length  12

UniProt ID  No entry found

Source  Synthetic construct(derived from HIV-1 integrase)

Target Organism  HIV

Assay  Integrase Assay

Activity 

• [Ref.16854053]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=186±23 µM);inhibition of strand transfer catalyzed by integrase(IC50=11±2 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Integrase

Mechanism  HIV-1 integrase (IN) is essential for viral replication. Following reverse transcription of the RNA into DNA by HIV-1 reverse transcriptase, IN integrates the viral DNA into the host genome.The peptide could inbibit integrase(By inhibiting the two steps of IN catalysis: 3′-processing and strand transfer).

PDB ID  None

Predicted Structure Download  DRAVPe00036

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.

Pubmed ID   16854053

Reference   J Med Chem. 2006 Jul 27;49(15):4477-86.

Author   Li HY, Zawahir Z, Song LD, Long YQ, Neamati N.

DOI   10.1021/jm060307u