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General Information
DRAVP ID DRAVPe00133
Peptide Name vif 45-59
Sequence ESTHPRISSEVHIPL
Sequence Length 15
UniProt ID No entry found
Taxon ID None
Source Synthetic construct(derived from HIV-1 Vif protein)
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not available
Activity Information
Target Organism HIV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Vif proteins
Mechanism Vif proteins are essential for HIV-1 replication and able to form multimer, which is critical to the biological activity of many prokaryotic and eukaryotic proteins and is a common mechanism for the functional activation/inactivation of proteins.The peptide could bind with vif proteins and block the multimerization of them,which should inhibit HIV-1 replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00133
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C74H120N22O24
Absent amino acids ACDFGKMNQWY
Common amino acids S
Mass 1701.9
Pl 6.01
Basic residues 3
Acidic residues 2
Hydrophobic residues 4
Net charge 1
Boman Index -3183
Hydrophobicity -48
Aliphatic Index 97.33
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency virus type 1 (HIV-1) Vif proteins.
Pubmed ID 12480936
Reference J Biol Chem. 2003 Feb 21;278(8):6596-602.
Author Yang B, Gao L, Li L, Lu Z, Fan X, Patel CA, Pomerantz RJ, DuBois GC, Zhang H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.