DRAVP ID  DRAVPe00166

Peptide Name   P1

Sequence  GTKALTEVIPLTEEAEC

Sequence Length  17

UniProt ID  No entry found

Source  Synthetic construct(derived from Pep-A)

Target Organism  HIV

Assay  RT-Polymerase Assay

Activity 

• [Ref.18952602]HIV-1: inhibition of polymerase activity of HIV-1 RT(Ki =7.5±2.3 μM);inhibition of PHA-P-activated PBMCs infected with HIV-1-LAI(EC50=78.2 nM,associated with Pep-1).
• NOTE:Ki: inhibition constants

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Reverse Transcriptase

Mechanism  HIV-1 reverse transcriptase (RT) plays an essential multifunctional role in the replication of the virus, by catalyzing the synthesis of double-stranded DNA from the single strand retroviral RNA genome.The peptide could inhibit the activity of reverse transcriptase.

PDB ID  None

Predicted Structure Download  DRAVPe00166

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility.

Pubmed ID   18952602

Reference   J Biol Chem. 2009 Jan 2;284(1):254-264.

Author   Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G.

DOI   10.1074/jbc.M802199200