To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00178
Peptide Name P13
Sequence GTKALTEVIPLAEEAEC
Sequence Length 17
UniProt ID No entry found
Source Synthetic construct(derived from Pep-A)
Activity Information
Target Organism HIV
Assay RT-Polymerase Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Reverse Transcriptase
Mechanism HIV-1 reverse transcriptase (RT) plays an essential multifunctional role in the replication of the virus, by catalyzing the synthesis of double-stranded DNA from the single strand retroviral RNA genome.The peptide could inhibit the activity of reverse transcriptase.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00178
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C76H128N18O28S
Absent amino acids DFHMNQRSWY
Common amino acids E
Mass 1774.02
Pl 4.09
Basic residues 1
Acidic residues 4
Hydrophobic residues 7
Net charge -3
Boman Index -1148
Hydrophobicity 17.06
Aliphatic Index 103.53
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility.
Pubmed ID 18952602
Reference J Biol Chem. 2009 Jan 2;284(1):254-264.
Author Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.