DRAVP ID  DRAVPe00189

Peptide Name   P29

Sequence  KWLTEWIPLTAEC

Sequence Length  13

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from Pep-A)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  RT-Polymerase Assay

Activity 

• [Ref.18952602]HIV-1:inhibition of polymerase activity of HIV-1 RT(Ki =1 ± 0.4 μM).
• NOTE:Ki: inhibition constants

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Reverse Transcriptase

Mechanism  HIV-1 reverse transcriptase (RT) plays an essential multifunctional role in the replication of the virus, by catalyzing the synthesis of double-stranded DNA from the single strand retroviral RNA genome.The peptide could inhibit the activity of reverse transcriptase.

PDB ID  None

Predicted Structure Download  DRAVPe00189

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility.

Pubmed ID   18952602

Reference   J Biol Chem. 2009 Jan 2;284(1):254-264.

Author   Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G.

DOI   10.1074/jbc.M802199200