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General Information
DRAVP ID DRAVPe00189
Peptide Name P29
Sequence KWLTEWIPLTAEC
Sequence Length 13
UniProt ID No entry found
Source Synthetic construct(derived from Pep-A)
Activity Information
Target Organism HIV
Assay RT-Polymerase Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Reverse Transcriptase
Mechanism HIV-1 reverse transcriptase (RT) plays an essential multifunctional role in the replication of the virus, by catalyzing the synthesis of double-stranded DNA from the single strand retroviral RNA genome.The peptide could inhibit the activity of reverse transcriptase.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00189
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C75H112N16O20S
Absent amino acids DFGHMNQRSVY
Common amino acids ELTW
Mass 1589.87
Pl 4.53
Basic residues 1
Acidic residues 2
Hydrophobic residues 6
Net charge -1
Boman Index -180
Hydrophobicity 5.38
Aliphatic Index 97.69
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 916.67
Polar residues 3
Literature Information
Literature 1
Title A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility.
Pubmed ID 18952602
Reference J Biol Chem. 2009 Jan 2;284(1):254-264.
Author Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.