General Information


DRAVP ID  DRAVPe00212

Peptide Name   VIRIP-amide

Sequence  LEAIPMSIPPEVKFNKPFVF

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct(derived from α1-antitrypsin)



Activity Information


Target Organism  HIV

Assay  ELISA

Activity 

  • [Ref.17448989]HIV-1:inhibition of virus infection in P4-CCR5 clls(IC50>100 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  The peptide can inhibit HIV-1 entry by binding to the gp41 FP and preventing its insertion into the target cell membrane.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C112H171N23O27S

Absent amino acids  CDGHQRTWY

Common amino acids  P

Mass  2303.79

Pl  6.14

Basic residues  2

Acidic residues  2

Hydrophobic residues  9

Net charge  0

Boman Index  118

Hydrophobicity  39

Aliphatic Index  92.5

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide.

Pubmed ID   17448989

Reference   Cell. 2007 Apr 20;129(2):263-75.

Author   Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F.

DOI   10.1016/j.cell.2007.02.042