General Information


DRAVP ID  DRAVPe00276

Peptide Name   p2(gag) peptide[ΔM4]

Sequence  AEASQVTNTATIM

Sequence Length  13

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Protease inhibition assay

Activity 

  • [Ref.15113844]HIV:inhibition of protease activity in CEM/LAV-1 cells(IC50=126 μM).

Hemolytic Activity 

Cytotoxicity 

Binding Target  autolysis

Mechanism  The peptide blocks the autolysis of HIV-1 virions for the conservation of viral species.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00276

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C54H93N15O22S

Absent amino acids  CDFGHKLPRWY

Common amino acids  AT

Mass  1336.48

Pl  4

Basic residues  0

Acidic residues  1

Hydrophobic residues  5

Net charge  -1

Boman Index  -1336

Hydrophobicity  20

Aliphatic Index  75.38

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Blocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. 

Pubmed ID   15113844

Reference   J Biochem. 2004 Mar;135(3):447-53. 

Author   Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S.

DOI   10.1093/jb/mvh052