General Information


DRAVP ID  DRAVPe00276

Peptide Name   p2(gag) peptide[ΔM4]

Sequence  AEASQVTNTATIM

Sequence Length  13

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HIV

Assay  Protease inhibition assay

Activity 

  • [Ref.15113844]HIV:inhibition of protease activity in CEM/LAV-1 cells(IC50=126 μM).

Hemolytic Activity 

Cytotoxicity 

Binding Target  autolysis

Mechanism  The peptide blocks the autolysis of HIV-1 virions for the conservation of viral species.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00276

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C54H93N15O22S

Absent amino acids  CDFGHKLPRWY

Common amino acids  AT

Mass  1336.48

Pl  4

Basic residues  0

Acidic residues  1

Hydrophobic residues  5

Net charge  -1

Boman Index  -1336

Hydrophobicity  20

Aliphatic Index  75.38

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Blocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. 

Pubmed ID   15113844

Reference   J Biochem. 2004 Mar;135(3):447-53. 

Author   Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S.

DOI   10.1093/jb/mvh052