To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00283
Peptide Name Circulin-F (CIRF; Plant defensin)
Sequence AIPCGESCVWIPCISAAIGCSCKNKVCYR
Sequence Length 29
UniProt ID P84644
Source Chassalia parviflora
Activity Information
Target Organism HIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00283
Linear/Cyclic Cyclic
N-terminal Modification Cyclization (N termini to C termini)
C-terminal Modification Cyclization (N termini to C termini)
Other Modification Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Stereochemistry L
Physicochemical Information
Formula C131H212N36O37S6
Absent amino acids DFHLMQT
Common amino acids C
Mass 3075.7
Pl 8.34
Basic residues 3
Acidic residues 1
Hydrophobic residues 10
Net charge 2
Boman Index -473
Hydrophobicity 65.17
Aliphatic Index 84.14
Half Life
Extinction Coefficient cystines 7365
Absorbance 280nm 263.04
Polar residues 13
Literature Information
Literature 1
Title Cyclotides as natural anti-HIV agents.
Pubmed ID 18008336
Reference Biopolymers. 2008;90(1):51-60.
Author Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.