DRAVP ID  DRAVPe00303

Peptide Name   Human defensin-6 (HD-6; Defensin, alpha 6; Human, mammals, animals)

Sequence  AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL

Sequence Length  32

UniProt ID  Q01524 

Taxon ID  None

Source  Homo sapiens (Human)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  SARS-CoV-2

Assay 

Activity 

• [Ref.34206990]SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(HD6 only blocked SARS-CoV-2 infection at the highest concentration tested (50 μg/mL, 13 μM)).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 μg/mL.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  1ZMQ  3QTE 

Predicted Structure Download  DRAVPe00303

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Disulfide bonds between Cys4 and Cys31,Cys6 and Cys20,Cys10 and Cys30.

Stereochemistry  L

Literature 1

Title   Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.

Pubmed ID   34206990

Reference   Viruses. 2021 Jun 26;13(7):1246.

Author   Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.

DOI   10.3390/v13071246