General Information


DRAVP ID  DRAVPe00304

Peptide Name   D70(Derived from Uperin 7.1)

Sequence  GWFDVVKHIAKRF

Sequence Length  13

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=2.99 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:50% Cell death at 10.6 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00304

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C78H115N21O16

Absent amino acids  CELMNPQSTY

Common amino acids  FKV

Mass  1602.9

Pl  9.99

Basic residues  4

Acidic residues  1

Hydrophobic residues  7

Net charge  3

Boman Index  -1536

Hydrophobicity  0

Aliphatic Index  82.31

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  458.33

Polar residues  1



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09