General Information


DRAVP ID  DRAVPe00307

Peptide Name   Mastoparan M

Sequence  INLKAIAALAKKLL

Sequence Length  14

UniProt ID  P04205 

Source  Hornet Vespa mandarinia



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>67.6 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >67.6 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00307

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C70H130N18O16

Absent amino acids  CDEFGHMPQRSTVWY

Common amino acids  AL

Mass  1479.91

Pl  10.3

Basic residues  3

Acidic residues  0

Hydrophobic residues  10

Net charge  3

Boman Index  1347

Hydrophobicity  115.71

Aliphatic Index  195.71

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09