General Information


DRAVP ID  DRAVPe00312

Peptide Name   Drosocin (insect)

Sequence  GKPRPYSPRPTSHPRPIRV

Sequence Length  19

UniProt ID  No entry found

Source  Drosophila melanogaster



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>45.5 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >45.5 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  4EZR 

Predicted Structure Download  DRAVPe00312

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C98H160N34O24

Absent amino acids  ACDEFLMNQW

Common amino acids  P

Mass  2198.56

Pl  12.01

Basic residues  6

Acidic residues  0

Hydrophobic residues  2

Net charge  6

Boman Index  -6950

Hydrophobicity  -157.89

Aliphatic Index  35.79

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  82.78

Polar residues  5



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09