General Information


DRAVP ID  DRAVPe00317

Peptide Name   Spinigerin (Insects, animals)

Sequence  HVDKKVADKVLLLKQLRIMRLLTRL

Sequence Length  25

UniProt ID  P82357 

Source  Pseudacanthotermes spiniger (Termite)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=3.05 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >33.3 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  1ZRW  1ZRV 

Predicted Structure Download  DRAVPe00317

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C136H247N41O32S

Absent amino acids  CEFGNPSWY

Common amino acids  L

Mass  3000.77

Pl  11.07

Basic residues  8

Acidic residues  2

Hydrophobic residues  12

Net charge  6

Boman Index  -4153

Hydrophobicity  15.6

Aliphatic Index  163.6

Half Life 

  •     Mammalian:3.5 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09