General Information

General Information

DRAVP ID DRAVPe00317

Peptide Name Spinigerin (Insects, animals)

Sequence HVDKKVADKVLLLKQLRIMRLLTRL

Sequence Length 25

UniProt ID P82357

Taxon ID None

Source Pseudacanthotermes spiniger (Termite)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HIV

Assay

Activity

[Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=3.05 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >33.3 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID 1ZRW 1ZRV

Predicted Structure Download DRAVPe00317

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C136H247N41O32S

Absent amino acids CEFGNPSWY

Common amino acids L

Mass 3000.77

Pl 11.07

Basic residues 8

Acidic residues 2

Hydrophobic residues 12

Net charge 6

Boman Index -4153

Hydrophobicity 15.6

Aliphatic Index 163.6

Half Life

Mammalian:3.5 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID 20086159

Reference Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI 10.1128/AAC.01448-09