General Information


DRAVP ID  DRAVPe00326

Peptide Name   B5(derived from Brevinin-2DYd)

Sequence  GIFDKLAKEISIW

Sequence Length  13

UniProt ID  No entry found

Source  Synthetic construct(derived from Brevinin-2DYd)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50>65.8 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >65.8 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00326

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C73H114N16O19

Absent amino acids  CHMNPQRTVY

Common amino acids  I

Mass  1519.8

Pl  6.07

Basic residues  2

Acidic residues  2

Hydrophobic residues  7

Net charge  0

Boman Index  -229

Hydrophobicity  38.46

Aliphatic Index  127.69

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  458.33

Polar residues  2



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09