General Information


DRAVP ID  DRAVPe00327

Peptide Name   B6(derived from Ponericin W3)

Sequence  GIWSDLAEIIKKF

Sequence Length  13

UniProt ID  No entry found

Source  Synthetic construct(derived from Ponericin W3)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=11.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >65.8 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00327

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C73H114N16O19

Absent amino acids  CHMNPQRTVY

Common amino acids  I

Mass  1519.8

Pl  6.07

Basic residues  2

Acidic residues  2

Hydrophobic residues  7

Net charge  0

Boman Index  -229

Hydrophobicity  38.46

Aliphatic Index  127.69

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  458.33

Polar residues  2



Literature Information


Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09