General Information

General Information

DRAVP ID DRAVPe00341

Peptide Name M-zodatoxin-Lt3a (M-ZDTX-Lt3a; Latarcin-3a, Ltc-3a; spiders, Arthropods, animals)

Sequence SWKSMAKKLKEYMEKLKQRA

Sequence Length 20

UniProt ID Q1ELU3

Source Lachesana tarabaevi (Spider)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=32.7 μM).

Hemolytic Activity

[Ref.16735513]20% hemolytic activity at >120 μM against rabbit erythrocytes

Cytotoxicity

[Ref.20086159]CEM-SS cells:TC50(cause 50% Cell death) >40.3 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00341

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C111H187N31O29S2

Absent amino acids CDFGHINPTV

Common amino acids K

Mass 2484.02

Pl 10.12

Basic residues 7

Acidic residues 2

Hydrophobic residues 5

Net charge 5

Boman Index -5383

Hydrophobicity -136

Aliphatic Index 49

Half Life

Mammalian:1.9 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 367.89

Polar residues 3

Literature Information

Literature 1

Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID 20086159

Reference Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI 10.1128/AAC.01448-09

Literature 2

Title Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.

Pubmed ID 16735513

Reference J Biol Chem. 2006 Jul 28;281(30):20983-209892.

Author Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.

DOI 10.1074/jbc.M602168200