DRAVP ID  DRAVPe00345

Peptide Name   Melectin (MEP; Insects, animals)

Sequence  GFLSILKKVLPKVMAHMK

Sequence Length  18

UniProt ID  P86170 

Taxon ID  None

Source  Melecta albifrons (Cuckoo bee) (Melecta punctata)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  HIV

Assay 

Activity 

• [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=4.34 μM).

Hemolytic Activity 

• [Ref.18942691]LC50>100 μM against rat red blood cells

Cytotoxicity 

• [Ref.20086159]CEM-SS cells:50% Cell death at 7.75 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  DRAVPe00345

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09

Literature 2

Title   Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons.

Pubmed ID   18942691

Reference   Chembiochem. 2008 Nov 24;9(17):2815-2821.

Author   Cerovský V, Hovorka O, Cvacka J, Voburka Z, Bednárová L, Borovicková L, Slaninová J, Fucík V.

DOI   10.1002/cbic.200800476