General Information

General Information

DRAVP ID DRAVPe00345

Peptide Name Melectin (MEP; Insects, animals)

Sequence GFLSILKKVLPKVMAHMK

Sequence Length 18

UniProt ID P86170

Source Melecta albifrons (Cuckoo bee) (Melecta punctata)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=4.34 μM).

Hemolytic Activity

[Ref.18942691]LC50>100 μM against rat red blood cells

Cytotoxicity

[Ref.20086159]CEM-SS cells:50% Cell death at 7.75 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00345

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C96H166N24O20S2

Absent amino acids CDENQRTWY

Common amino acids K

Mass 2040.64

Pl 10.48

Basic residues 5

Acidic residues 0

Hydrophobic residues 8

Net charge 5

Boman Index 793

Hydrophobicity 61.67

Aliphatic Index 124.44

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID 20086159

Reference Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI 10.1128/AAC.01448-09

Literature 2

Title Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons.

Pubmed ID 18942691

Reference Chembiochem. 2008 Nov 24;9(17):2815-2821.

Author Cerovský V, Hovorka O, Cvacka J, Voburka Z, Bednárová L, Borovicková L, Slaninová J, Fucík V.

DOI 10.1002/cbic.200800476