DRAVP ID  DRAVPe00350

Peptide Name   Maximin-4 (Toads, amphibians, animals)

Sequence  GIGGVLLSAGKAALKGLAKVLAEKYAN

Sequence Length  27

UniProt ID  P83083  Q58T42  Q58T44  Q58T52  Q58T62  Q58T77  Q58T79 

Source  Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

Target Organism  HIV

Assay 

Activity 

• [Ref.11835991]HIV-1:inhibition the cytopathic effects of HIV-1 (IC50=24.2 µg/ml, EC50=21.9 µg/ml).
• NOTE: IC50 means the concentration that can inhibit 50% growth of cells. EC50 was defined as the concentration of antiviral agent reducing HIV-1 replication by 50%.

Hemolytic Activity 

• [Ref:11835991]Little hemolytic activity at 50 μg/ml against red blood cells

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2MHW 

Predicted Structure Download  DRAVPe00350

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.

Pubmed ID   11835991

Reference   Peptides. 2002 Mar;23(3):427-435.

Author   Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y.

DOI