To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00357
Peptide Name Caerin-1.19
Sequence GLFKVLGSVAKHLLPHVAPIIAEKL
Sequence Length 25
UniProt ID P0C2A8
Source Litoria gracilenta (Dainty green tree frog)
Activity Information
Target Organism HIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide could disrupt the viral envelope and release p24 protein.And the more effective they were at disruption of the viral envelope, the better they were at inhibiting infection.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00357
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C127H212N32O29
Absent amino acids CDMNQRTWY
Common amino acids L
Mass 2651.28
Pl 9.7
Basic residues 5
Acidic residues 1
Hydrophobic residues 14
Net charge 4
Boman Index 2067
Hydrophobicity 89.6
Aliphatic Index 156
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Inhibition of HIV infection by caerin 1 antimicrobial peptides.
Pubmed ID 26026377
Reference Peptides. 2015 Sep;71:296-303.
Author VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.