General Information

General Information

DRAVP ID DRAVPe00358

Peptide Name Caerin 1.10

Sequence GLLSVLGSVAKHVLPHVVPVIAEKL

Sequence Length 25

UniProt ID P86502 P82104

Source Litoria splendida

Activity Information

Target Organism HIV

Assay

Activity

[Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 µM.

Binding Target virion envelope

Mechanism Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00358

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C121H207N31O30

Absent amino acids CDFMNQRTWY

Common amino acids V

Mass 2576.16

Pl 8.61

Basic residues 4

Acidic residues 1

Hydrophobic residues 14

Net charge 3

Boman Index 2523

Hydrophobicity 116

Aliphatic Index 171.2

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID 26026377

Reference Peptides. 2015 Sep;71:296-303.

Author Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI 10.1016/j.peptides.2015.05.004

Literature 2

Title Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.

Pubmed ID 33008028

Reference Antibiotics (Basel). 2020 Sep 30;9(10):661.

Author Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.

DOI 10.3390/antibiotics9100661