General Information


DRAVP ID  DRAVPe00358

Peptide Name   Caerin 1.10

Sequence  GLLSVLGSVAKHVLPHVVPVIAEKL

Sequence Length  25

UniProt ID  P86502  P82104 

Source  Litoria splendida



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 µM.

Binding Target  virion envelope

Mechanism  Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00358

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C121H207N31O30

Absent amino acids  CDFMNQRTWY

Common amino acids  V

Mass  2576.16

Pl  8.61

Basic residues  4

Acidic residues  1

Hydrophobic residues  14

Net charge  3

Boman Index  2523

Hydrophobicity  116

Aliphatic Index  171.2

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4



Literature Information


Literature 1

Title   VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID   26026377

Reference   Peptides. 2015 Sep;71:296-303.

Author   Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI   10.1016/j.peptides.2015.05.004

Literature 2

Title   Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.

Pubmed ID   33008028

Reference   Antibiotics (Basel). 2020 Sep 30;9(10):661.

Author   Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.

DOI   10.3390/antibiotics9100661