DRAVP ID  DRAVPe00362

Peptide Name   Caerin 1.1 mod 9(Caerin 1.1 [E23K,H24L,L25H])

Sequence  GLLSVLGSVAKHVLPHVVPVIAKLH

Sequence Length  25

UniProt ID  No entry found

Taxon ID  None

Source  Sythetic construct(derived from Caerin 1.1)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  HIV

Assay 

Activity 

• [Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 17 µM.

Binding Target  virion envelope

Mechanism  [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).

PDB ID  None

Predicted Structure Download  DRAVPe00362

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID   26026377

Reference   Peptides. 2015 Sep;71:296-303.

Author   Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI   10.1016/j.peptides.2015.05.004