General Information

General Information

DRAVP ID DRAVPe00362

Peptide Name Caerin 1.1 mod 9(Caerin 1.1 [E23K,H24L,L25H])

Sequence GLLSVLGSVAKHVLPHVVPVIAKLH

Sequence Length 25

UniProt ID No entry found

Source Sythetic construct(derived from Caerin 1.1)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 17 µM.

Binding Target virion envelope

Mechanism [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00362

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C122H207N33O28

Absent amino acids CDEFMNQRTWY

Common amino acids V

Mass 2584.19

Pl 10

Basic residues 5

Acidic residues 0

Hydrophobic residues 14

Net charge 5

Boman Index 2738

Hydrophobicity 117.2

Aliphatic Index 171.2

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID 26026377

Reference Peptides. 2015 Sep;71:296-303.

Author Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI 10.1016/j.peptides.2015.05.004