General Information

General Information

DRAVP ID DRAVPe00364

Peptide Name Caerin 1.9 sm(Caerin 1.9 [V13L])

Sequence GLFGVLGSIAKHLLPHVVPVIAEKL

Sequence Length 25

UniProt ID No entry found

Source Sythetic construct(derived from Caerin 1.9)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 17.5 µM.

Binding Target virion envelope

Mechanism [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00364

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C125H207N31O29

Absent amino acids CDMNQRTWY

Common amino acids L

Mass 2608.21

Pl 8.61

Basic residues 4

Acidic residues 1

Hydrophobic residues 14

Net charge 3

Boman Index 2939

Hydrophobicity 113.2

Aliphatic Index 163.6

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID 26026377

Reference Peptides. 2015 Sep;71:296-303.

Author Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI 10.1016/j.peptides.2015.05.004

Literature 2

Title Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.

Pubmed ID 33008028

Reference Antibiotics (Basel). 2020 Sep 30;9(10):661.

Author Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.

DOI 10.3390/antibiotics9100661