General Information


DRAVP ID  DRAVPe00364

Peptide Name   Caerin 1.9 sm(Caerin 1.9 [V13L])

Sequence  GLFGVLGSIAKHLLPHVVPVIAEKL

Sequence Length  25

UniProt ID  No entry found

Source  Sythetic construct(derived from Caerin 1.9)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 17.5 µM.

Binding Target  virion envelope

Mechanism  [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00364

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C125H207N31O29

Absent amino acids  CDMNQRTWY

Common amino acids  L

Mass  2608.21

Pl  8.61

Basic residues  4

Acidic residues  1

Hydrophobic residues  14

Net charge  3

Boman Index  2939

Hydrophobicity  113.2

Aliphatic Index  163.6

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4



Literature Information


Literature 1

Title   VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID   26026377

Reference   Peptides. 2015 Sep;71:296-303.

Author   Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI   10.1016/j.peptides.2015.05.004

Literature 2

Title   Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.

Pubmed ID   33008028

Reference   Antibiotics (Basel). 2020 Sep 30;9(10):661.

Author   Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.

DOI   10.3390/antibiotics9100661