General Information

General Information

DRAVP ID DRAVPe00368

Peptide Name Ctry2459-H3 (Ctry2459 peptide derivative, His-rich)

Sequence FLHFLHHLF

Sequence Length 9

UniProt ID No entry found

Source Synthetic construct(from a scorpion venom peptide library)

Activity Information

Target Organism HCV

Assay

Activity

[Ref.23415044]Hepatitis C virus:inhibition of infection with HCV in Huh 7.5.1 cells (EC50=0.85 μg/ml).

Hemolytic Activity

[Ref.23415044] HC50 = 416.4 μg/ml against human red blood cells.

Cytotoxicity

[Ref.23415044] CC50>500 μg/ml against Huh7.5.1 cells

Binding Target Not found

Mechanism The peptide effectively enter the cells, break through the endosomes, interact with the mature viral particles, and exhibit significant antiviral activities.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00368

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C63H83N15O10

Absent amino acids ACDEGIKMNPQRSTVWY

Common amino acids FHL

Mass 1210.45

Pl 7.02

Basic residues 3

Acidic residues 0

Hydrophobic residues 6

Net charge 3

Boman Index 972

Hydrophobicity 113.33

Aliphatic Index 130

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

Pubmed ID 23415044

Reference Biomaterials. 2013 Apr;34(13):3511-22.

Author Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.

DOI 10.1016/j.biomaterials.2013.01.075