General Information
DRAVP ID DRAVPe00368
Peptide Name Ctry2459-H3 (Ctry2459 peptide derivative, His-rich)
Sequence FLHFLHHLF
Sequence Length 9
UniProt ID No entry found
Source Synthetic construct(from a scorpion venom peptide library)
Activity Information
Target Organism HCV
Assay
Activity
Hemolytic Activity
Cytotoxicity
Binding Target Not found
Mechanism The peptide effectively enter the cells, break through the endosomes, interact with the mature viral particles, and exhibit significant antiviral activities.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00368
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C63H83N15O10
Absent amino acids ACDEGIKMNPQRSTVWY
Common amino acids FHL
Mass 1210.45
Pl 7.02
Basic residues 3
Acidic residues 0
Hydrophobic residues 6
Net charge 3
Boman Index 972
Hydrophobicity 113.33
Aliphatic Index 130
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.
Pubmed ID 23415044
Reference Biomaterials. 2013 Apr;34(13):3511-22.
Author Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.