DRAVP ID  DRAVPe00368

Peptide Name   Ctry2459-H3 (Ctry2459 peptide derivative, His-rich)

Sequence  FLHFLHHLF

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(from a scorpion venom peptide library)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HCV

Assay 

Activity 

• [Ref.23415044]Hepatitis C virus:inhibition of infection with HCV in Huh 7.5.1 cells (EC50=0.85 μg/ml).

Hemolytic Activity 

• [Ref.23415044] HC50 = 416.4 μg/ml against human red blood cells.

Cytotoxicity 

• [Ref.23415044] CC50>500 μg/ml against Huh7.5.1 cells

Binding Target  Not found

Mechanism  The peptide effectively enter the cells, break through the endosomes, interact with the mature viral particles, and exhibit significant antiviral activities.

PDB ID  None

Predicted Structure Download  DRAVPe00368

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

Pubmed ID   23415044

Reference   Biomaterials. 2013 Apr;34(13):3511-22.

Author   Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.

DOI   10.1016/j.biomaterials.2013.01.075