General Information


DRAVP ID  DRAVPe00368

Peptide Name   Ctry2459-H3 (Ctry2459 peptide derivative, His-rich)

Sequence  FLHFLHHLF

Sequence Length  9

UniProt ID  No entry found

Source  Synthetic construct(from a scorpion venom peptide library)



Activity Information


Target Organism  HCV

Assay 

Activity 

  • [Ref.23415044]Hepatitis C virus:inhibition of infection with HCV in Huh 7.5.1 cells (EC50=0.85 μg/ml).

Hemolytic Activity 

  • [Ref.23415044] HC50 = 416.4 μg/ml against human red blood cells.

Cytotoxicity 

  • [Ref.23415044] CC50>500 μg/ml against Huh7.5.1 cells

Binding Target  Not found

Mechanism  The peptide effectively enter the cells, break through the endosomes, interact with the mature viral particles, and exhibit significant antiviral activities.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00368

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C63H83N15O10

Absent amino acids  ACDEGIKMNPQRSTVWY

Common amino acids  FHL

Mass  1210.45

Pl  7.02

Basic residues  3

Acidic residues  0

Hydrophobic residues  6

Net charge  3

Boman Index  972

Hydrophobicity  113.33

Aliphatic Index  130

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

Pubmed ID   23415044

Reference   Biomaterials. 2013 Apr;34(13):3511-22.

Author   Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.

DOI   10.1016/j.biomaterials.2013.01.075