DRAVP ID  DRAVPe00369

Peptide Name   Temporin A

Sequence  FLPLIGRVLSGIL

Sequence Length  13

UniProt ID  P56917 

Source  Rana temporaria (European common frog)

Target Organism  CCV,FV3

Assay 

Activity 

• [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 15 μM);
• Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 58 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2MAA 

Predicted Structure Download  DRAVPe00369

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029