General Information

General Information

DRAVP ID DRAVPe00371

Peptide Name Piscidin-1

Sequence FFHHIFRGIVHVGKTIHRLVTG

Sequence Length 22

UniProt ID Q8UUG0

Source Morone saxatilis (Striped bass)

Activity Information

Target Organism CCV,FV3

Assay

Activity

[Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 4 μM);
Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 13 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.11601906]No cytotoxicity against catfish ovary(CCO) cells at 0.25-25μg/ ml.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID 2JOS 2OJM

Predicted Structure Download DRAVPe00371

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C122H187N37O25

Absent amino acids ACDEMNPQSWY

Common amino acids H

Mass 2572.06

Pl 12.01

Basic residues 7

Acidic residues 0

Hydrophobic residues 10

Net charge 7

Boman Index -1561

Hydrophobicity 45.45

Aliphatic Index 110.45

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID 15193922

Reference Virology. 2004 Jun 1;323(2):268-75.

Author Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI 10.1016/j.virol.2004.02.029