General Information
DRAVP ID DRAVPe00375
Peptide Name Esculentin-2P (Frogs, amphibians, animals)
Sequence GFLSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Sequence Length 37
UniProt ID P82846
Source Rana pipiens (northern leopard frog)
Activity Information
Target Organism FV3,CCV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00375
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Cyclization of a C-terminal Cys residue (forming a disulfide bond)
Other Modification There is a disulfide bond between Cys31 and Cys37.
Stereochemistry L
Physicochemical Information
Formula C176H296N50O45S2
Absent amino acids EHMPTWY
Common amino acids GKL
Mass 3896.71
Pl 10.21
Basic residues 7
Acidic residues 1
Hydrophobic residues 17
Net charge 6
Boman Index -1869
Hydrophobicity 48.11
Aliphatic Index 108.11
Half Life
Extinction Coefficient cystines 125
Absorbance 280nm 3.47
Polar residues 11
Literature Information
Literature 1
Title Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.
Pubmed ID 11601906
Reference Virology. 2001 Sep 30;288(2):351-7.
Author Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.