General Information
DRAVP ID DRAVPe00376
Peptide Name Temporin L(TL)
Sequence FVQWFSKFLGRIL
Sequence Length 13
UniProt ID P57104
Source Rana temporaria (European common frog)
Activity Information
Target Organism HSV
Assay
Activity
Hemolytic Activity
Cytotoxicity
Binding Target membrane
Mechanism TL peptides may be able to selectively induce pore formation in highly curved membrane structures (below ~250 nm in diameter), resulting in membrane lysis once a critical number of pores is formed, with the consequence of viral infectivity reduction.
Structure Information
PDB ID 6GS5
Predicted Structure Download DRAVPe00376
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C83H121N19O16
Absent amino acids ACDEHMNPTY
Common amino acids F
Mass 1640.99
Pl 11
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 160
Hydrophobicity 82.31
Aliphatic Index 112.31
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 2
Literature Information
Literature 1
Title Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs.
Pubmed ID 35216177
Reference Int J Mol Sci. 2022 Feb 13;23(4):2060.
Author Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M.