General Information
DRAVP ID DRAVPe00381
Peptide Name Temporin L[Pro3,DLeu9,DHyp10](TL5)
Sequence FVPWFSKFlxRIL
Sequence Length 13
UniProt ID No entry found
Source Synthetic construct(derived from Temporin-L)
Activity Information
Target Organism SARS-CoV-2,HSV,HCoV-OC43,HPIV-3,HCoV-229E
Assay
Activity
Hemolytic Activity
Cytotoxicity
Binding Target membrane
Mechanism TL peptides may be able to selectively induce pore formation in highly curved membrane structures (below ~250 nm in diameter), resulting in membrane lysis once a critical number of pores is formed, with the consequence of viral infectivity reduction.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification The 'x' at position 10 is D-hydroxyproline (Hyp).
Stereochemistry Mixed(D-Leu9,D-Hyp10)
Physicochemical Information
Formula C75H102N16O11
Absent amino acids ACDEGHMNQTY
Common amino acids F
Mass 1664.26
Pl 11
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index 128
Hydrophobicity 70.77
Aliphatic Index 82.31
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 1
Literature Information
Literature 1
Title Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs.
Pubmed ID 35216177
Reference Int J Mol Sci. 2022 Feb 13;23(4):2060.
Author Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M.