General Information

General Information

DRAVP ID DRAVPe00398

Peptide Name Dermaseptin K4S4

Sequence ALWKTLLKKVLKAAAKAALNAVLVGANA

Sequence Length 28

UniProt ID No entry found

Source Synthetic construct(derived from Dermaseptin S4)

Activity Information

Target Organism HSV

Assay

Activity

[Ref.23161023]HSV-2 acyclovir-sensitive strain(911411):inhibition the cytopathic effect(CPE) of HSV-2 in Vero cells(EC50=2.7 μM);
HSV-2 acyclovir-resistant strain(ROI2):inhibition of cytopathic effet(CPE) of HSV-2 in Vero cells(EC50=5.1 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.23161023]Vero cells:CC50=12 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00398

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C133H232N36O32

Absent amino acids CDEFHIMPQRSY

Common amino acids A

Mass 2847.53

Pl 10.6

Basic residues 5

Acidic residues 0

Hydrophobic residues 19

Net charge 5

Boman Index 1760

Hydrophobicity 82.5

Aliphatic Index 146.79

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 203.7

Polar residues 4

Literature Information

Literature 1

Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2.

Pubmed ID 23161023

Reference J Med Virol. 2013 Feb;85(2):272-81.

Author Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K.

DOI 10.1002/jmv.23450