General Information


DRAVP ID  DRAVPe00398

Peptide Name   Dermaseptin K4S4

Sequence  ALWKTLLKKVLKAAAKAALNAVLVGANA

Sequence Length  28

UniProt ID  No entry found

Source  Synthetic construct(derived from Dermaseptin S4)



Activity Information


Target Organism  HSV

Assay 

Activity 

  • [Ref.23161023]HSV-2 acyclovir-sensitive strain(911411):inhibition the cytopathic effect(CPE) of HSV-2 in Vero cells(EC50=2.7 μM);
  • HSV-2 acyclovir-resistant strain(ROI2):inhibition of cytopathic effet(CPE) of HSV-2 in Vero cells(EC50=5.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.23161023]Vero cells:CC50=12 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00398

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C133H232N36O32

Absent amino acids  CDEFHIMPQRSY

Common amino acids  A

Mass  2847.53

Pl  10.6

Basic residues  5

Acidic residues  0

Hydrophobic residues  19

Net charge  5

Boman Index  1760

Hydrophobicity  82.5

Aliphatic Index  146.79

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  203.7

Polar residues  4



Literature Information


Literature 1

Title    In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2.

Pubmed ID   23161023

Reference   J Med Virol. 2013 Feb;85(2):272-81.

Author   Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K. 

DOI   10.1002/jmv.23450