General Information
DRAVP ID DRAVPe00429
Peptide Name IBP27
Sequence SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK
Sequence Length 37
UniProt ID No entry found
Source Synthetic construct(derived from HR2 region of SARS-CoV-2)
Activity Information
Target Organism SARS-CoV-2,SARS-CoV,MERS-CoV,HCoV-NL63
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification PEG8-K(Chol)
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C192H317N51O63
Absent amino acids CFHMPTW
Common amino acids EL
Mass 4347.93
Pl 4.77
Basic residues 5
Acidic residues 7
Hydrophobic residues 13
Net charge -2
Boman Index -7972
Hydrophobicity -60.27
Aliphatic Index 121.08
Half Life
Extinction Coefficient cystines 2980
Absorbance 280nm 82.78
Polar residues 9
Literature Information
Literature 1
Title Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants.
Pubmed ID 34057039
Reference Emerg Microbes Infect. 2021 Dec;10(1):1227-1240.
Author Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y.