To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00466
Peptide Name WN82
Sequence VVDRGWGNGAGLFGKGSID
Sequence Length 19
UniProt ID No entry found
Taxon ID None
Source Synthetic construct(derived from the E polyprotein of WNV)
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism WNV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope
Mechanism The peptide may play roles in protein-protein rearrangements or bilayer membrane interactions during the entry and fusion process and thus inhibit infection of DENV or WNV.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00466
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C84H129N25O26
Absent amino acids CEHMPQTY
Common amino acids G
Mass 1905.1
Pl 5.93
Basic residues 2
Acidic residues 2
Hydrophobic residues 7
Net charge 0
Boman Index -1727
Hydrophobicity -8.95
Aliphatic Index 76.84
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 305.56
Polar residues 8
Literature Information
Literature 1
Title Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.
Pubmed ID 31351847
Reference Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978.
Author da Silva-Júnior EF, de Araújo-Júnior JX.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.