General Information
DRAVP ID DRAVPe00485
Peptide Name HIV-1 integrase(95-109)
Sequence QETAYFLLKLAGRWP
Sequence Length 15
UniProt ID P04587
Source Synthetic construct(derived from HIV-1 integrase)
Activity Information
Target Organism HIV
Assay HIV-1 Integrase 30 -DNA Processing Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Integrase
Mechanism The peptide can inhibit the activity of integrase and thus inhibit virus repliaction.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00485
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C86H129N21O21
Absent amino acids CDHIMNSV
Common amino acids L
Mass 1793.1
Pl 8.59
Basic residues 2
Acidic residues 1
Hydrophobic residues 7
Net charge 1
Boman Index -1090
Hydrophobicity -16.67
Aliphatic Index 91.33
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 499.29
Polar residues 3
Literature Information
Literature 1
Title Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.
Pubmed ID 12643937
Reference Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7.
Author Zhao L, O'Reilly MK, Shultz MD, Chmielewski J.