General Information


DRAVP ID  DRAVPe00485

Peptide Name   HIV-1 integrase(95-109)

Sequence  QETAYFLLKLAGRWP

Sequence Length  15

UniProt ID  P04587 

Source  Synthetic construct(derived from HIV-1 integrase)



Activity Information


Target Organism  HIV

Assay  HIV-1 Integrase 30 -DNA Processing Assay

Activity 

  • [Ref.12643937]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=3.5 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Integrase

Mechanism  The peptide can inhibit the activity of integrase and thus inhibit virus repliaction.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00485

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C86H129N21O21

Absent amino acids  CDHIMNSV

Common amino acids  L

Mass  1793.1

Pl  8.59

Basic residues  2

Acidic residues  1

Hydrophobic residues  7

Net charge  1

Boman Index  -1090

Hydrophobicity  -16.67

Aliphatic Index  91.33

Half Life 

  •     Mammalian:0.8 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  6990

Absorbance 280nm  499.29

Polar residues  3



Literature Information


Literature 1

Title   Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization. 

Pubmed ID   12643937

Reference   Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7.

Author   Zhao L, O'Reilly MK, Shultz MD, Chmielewski J.

DOI   10.1016/s0960-894x(03)00040-4