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General Information
DRAVP ID DRAVPe00486
Peptide Name HIV-1 integrase(123-133)
Sequence STTVKAASWWA
Sequence Length 11
UniProt ID P04587
Source Synthetic construct(derived from HIV-1 integrase)
Activity Information
Target Organism HIV
Assay HIV-1 Integrase 30 -DNA Processing Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Integrase
Mechanism The peptide can inhibit the activity of integrase and thus inhibit virus repliaction.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00486
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C56H82N14O16
Absent amino acids CDEFGHILMNPQRY
Common amino acids A
Mass 1207.35
Pl 8.47
Basic residues 1
Acidic residues 0
Hydrophobic residues 6
Net charge 1
Boman Index -336
Hydrophobicity 8.18
Aliphatic Index 53.64
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 1100
Polar residues 4
Literature Information
Literature 1
Title Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.
Pubmed ID 12643937
Reference Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7.
Author Zhao L, O'Reilly MK, Shultz MD, Chmielewski J.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.