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General Information
DRAVP ID DRAVPe00495
Peptide Name LEDGF 361–370[K364A]
Sequence WNSLAIDNLDV
Sequence Length 11
UniProt ID O75475
Source Synthetic construct
Activity Information
Target Organism HIV
Assay quantitative assay(IN enzymatic activity)
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Integrase
Mechanism The peptide inhibits the catalytic activity of integrase and thus inhibits integration of viral cDNA.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00495
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C56H86N14O19
Absent amino acids CEFGHKMPQRTY
Common amino acids DLN
Mass 1259.38
Pl 3.56
Basic residues 0
Acidic residues 2
Hydrophobic residues 6
Net charge -2
Boman Index -1118
Hydrophobicity 21.82
Aliphatic Index 141.82
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 550
Polar residues 3
Literature Information
Literature 1
Title Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370.
Pubmed ID 20171172
Reference Biochem Biophys Res Commun. 2010 Apr 2;394(2):260-5.
Author Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.