General Information

General Information

DRAVP ID DRAVPe00529

Peptide Name peptide 12

Sequence EEIIRKLQQLLFIHFRIGRRRRRRRR

Sequence Length 26

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HIV

Assay Integrase assay

Activity

[Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.12 ± 0.01 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.047 ± 0.01 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Integrase

Mechanism The peptide acts antiviral activity by inhibiting the activity of integrase.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00529

Linear/Cyclic Linear

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C154H269N61O33

Absent amino acids ACDMNPSTVWY

Common amino acids R

Mass 3503.22

Pl 12.37

Basic residues 12

Acidic residues 2

Hydrophobic residues 9

Net charge 10

Boman Index -14277

Hydrophobicity -121.15

Aliphatic Index 105

Half Life

Mammalian:1 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Pubmed ID 20708407

Reference Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

Author Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.

DOI 10.1016/j.bmc.2010.07.050