General Information


DRAVP ID  DRAVPe00530

Peptide Name   peptide 13

Sequence  EAIIRILQELLFKHFRIGRRRRRRRR

Sequence Length  26

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Integrase assay

Activity 

  • [Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.14 ± 0.02 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.065 ± 0.01 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Integrase

Mechanism  The peptide acts antiviral activity by inhibiting the activity of integrase.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00530

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C152H266N60O32

Absent amino acids  CDMNPSTVWY

Common amino acids  R

Mass  3446.17

Pl  12.37

Basic residues  12

Acidic residues  2

Hydrophobic residues  10

Net charge  10

Boman Index  -13542

Hydrophobicity  -100.77

Aliphatic Index  108.85

Half Life 

  •     Mammalian:1 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Pubmed ID   20708407

Reference   Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

Author   Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.

DOI   10.1016/j.bmc.2010.07.050