General Information

General Information

DRAVP ID DRAVPe00538

Peptide Name peptide 21

Sequence LQQALFIHFRIGRRRRRRRR

Sequence Length 20

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HIV

Assay Integrase assay

Activity

[Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.12 ± 0.02 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.07 ± 0.01 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Integrase

Mechanism The peptide acts antiviral activity by inhibiting the activity of integrase.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00538

Linear/Cyclic Linear

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C117H203N51O23

Absent amino acids CDEKMNPSTVWY

Common amino acids R

Mass 2692.23

Pl 12.9

Basic residues 10

Acidic residues 0

Hydrophobic residues 7

Net charge 10

Boman Index -12163

Hydrophobicity -135.5

Aliphatic Index 83

Half Life

Mammalian:5.5 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Pubmed ID 20708407

Reference Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

Author Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.

DOI 10.1016/j.bmc.2010.07.050