General Information


DRAVP ID  DRAVPe00538

Peptide Name   peptide 21

Sequence  LQQALFIHFRIGRRRRRRRR

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Integrase assay

Activity 

  • [Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.12 ± 0.02 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.07 ± 0.01 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Integrase

Mechanism  The peptide acts antiviral activity by inhibiting the activity of integrase.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00538

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C117H203N51O23

Absent amino acids  CDEKMNPSTVWY

Common amino acids  R

Mass  2692.23

Pl  12.9

Basic residues  10

Acidic residues  0

Hydrophobic residues  7

Net charge  10

Boman Index  -12163

Hydrophobicity  -135.5

Aliphatic Index  83

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Pubmed ID   20708407

Reference   Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

Author   Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.

DOI   10.1016/j.bmc.2010.07.050