DRAVP ID  DRAVPe00548

Peptide Name   C12- N27

Sequence  RQLLSGIVQQQNNLLRAIEAQQHLLQK

Sequence Length  27

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  cell-cell fusion inhibition assay

Activity 

• [Ref.20605950]HIV-1:inhibition of peptide against cell-cell fusion between Jurkat E6-1 and HXBc2 cells(IC50=473±74 nM);inhibition of peptide against virus-cell fusion on CD4-expressing cells(IC50=182±15 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  N peptide may target an exposed C-helix region of gp41 and can interact with their coiled coil formation within a gp41 dimer,which can inhibit HIV-1 entry.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  C12(dodecanoic acid)

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Virus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain. 

Pubmed ID   20605950

Reference   FASEB J. 2010 Nov;24(11):4196-202. 

Author   Wexler-Cohen Y, Ashkenazi A, Viard M, Blumenthal R, Shai Y.

DOI   10.1096/fj.09-151704