To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00572
Peptide Name P21
Sequence LDLTYEMLSLQQVVKALNESY
Sequence Length 21
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism MERS-CoV
Assay Inhibition of MERS-CoV S-Protein-Mediated Cell–Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide inhibits MERS-CoV infection and its spike (S) protein-mediated cell–cell fusion.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00572
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C110H177N25O36S
Absent amino acids CFGHIPRW
Common amino acids L
Mass 2457.82
Pl 4.14
Basic residues 1
Acidic residues 3
Hydrophobic residues 8
Net charge -2
Boman Index -1842
Hydrophobicity 6.19
Aliphatic Index 125.24
Half Life
Extinction Coefficient cystines 2980
Absorbance 280nm 149
Polar residues 6
Literature Information
Literature 1
Title Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors.
Pubmed ID 29442512
Reference J Med Chem. 2018 Mar 8;61(5):2018-2026.
Author Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.