General Information


DRAVP ID  DRAVPe00623

Peptide Name   peptide 4(RSV fusion protein(497-515))

Sequence  EKINQSLAFIRKSDELLHNV

Sequence Length  20

UniProt ID  P03420 

Taxon ID  None

Source  Synthetic construct(derived from RSV fusion protein)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available



Activity Information


Target Organism  RSV

Assay  rHRSV-mCherry inhibition assay

Activity 

  • [Ref.28137809]Respiratory syncytial virus (RSV):inhibition of virus infection in Hep-2 cells(EC50>50 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  The peptide disrupts the formation of the postfusion six-helix bundle required for viral cell entry.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00623

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C104H172N30O32

Absent amino acids  CGMPTWY

Common amino acids  L

Mass  2354.69

Pl  6.86

Basic residues  4

Acidic residues  3

Hydrophobic residues  8

Net charge  1

Boman Index  -4521

Hydrophobicity  -44.5

Aliphatic Index  117

Half Life 

  •     Mammalian:1 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4



Literature Information


Literature 1

Title  

Pubmed ID  

Reference  

Author  

DOI