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General Information
DRAVP ID DRAVPe00635
Peptide Name peptide 4bb[S502A]
Sequence EKIXQALXFIXKSDXLLHNV
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism RSV
Assay rHRSV-mCherry inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide disrupts the formation of the postfusion six-helix bundle required for viral cell entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification The 'X' at position 4,8,11,15 indicates S-pentenylalanine, X(4) and X(8), X(11) and X(15) are cross-linked by hydrocarbon stapling.
Stereochemistry L
Physicochemical Information
Formula C86H134N22O20
Absent amino acids CGMPRTWY
Common amino acids X
Mass 2313.53
Pl 6.85
Basic residues 3
Acidic residues 2
Hydrophobic residues 8
Net charge 1
Boman Index -1344
Hydrophobicity 17
Aliphatic Index 117
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.
Pubmed ID 28137809
Reference Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02241-16.
Author Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.