DRAVP ID  DRAVPe00639

Peptide Name   peptide 4bb[K508A]

Sequence  EKIXQSLXFIXASDXLLHNV

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  RSV

Assay  rHRSV-mCherry inhibition assay

Activity 

• [Ref.28137809]Respiratory syncytial virus (RSV):inhibition of virus infection in Hep-2 cells(EC50=10.93±13.90 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  membrane

Mechanism  The peptide disrupts the formation of the postfusion six-helix bundle required for viral cell entry.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Acetylation

C-terminal Modification  Free

Other Modification  The 'X' at position 4,8,11,15 indicates S-pentenylalanine, X(4) and X(8), X(11) and X(15) are cross-linked by hydrocarbon stapling.

Stereochemistry  L

Literature 1

Title   A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.

Pubmed ID   28137809

Reference   Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02241-16.

Author   Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O.

DOI   10.1128/AAC.02241-16