General Information


DRAVP ID  DRAVPe00705

Peptide Name   peptide derived from hydrolysate of oyster

Sequence  LLEYS

Sequence Length  5

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  HIV-1 protease inhibition assay

Activity 

  • [Ref.9918775]HIV-1:inhibition of HIV-1 protease(IC50=120 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  HIV-1 protease

Mechanism  The HIV-1 protease is a virally encoded protease that serves to cleave the gag and gag-pol polyprotein precursor into mature, functional proteins. This specific proteolysis occurs late in the viral life cycle and is essential for the maturation of the infectious virus. The peptide inhibits HIV-1 protease and thus acts antiviral activity.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00705

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C29H45N5O10

Absent amino acids  ACDFGHIKMNPQRTVW

Common amino acids  L

Mass  623.7

Pl  4

Basic residues  0

Acidic residues  1

Hydrophobic residues  2

Net charge  -1

Boman Index  -51

Hydrophobicity  40

Aliphatic Index  156

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  1490

Absorbance 280nm  372.5

Polar residues  2



Literature Information


Literature 1

Title   Isolation of HIV-1 protease-inhibiting peptides from thermolysin hydrolysate of oyster proteins.

Pubmed ID   9918775

Reference   Biochem Biophys Res Commun. 1998 Dec 30;253(3):604-8.

Author   Lee TG, Maruyama S. 

DOI   10.1006/bbrc.1998.9824