General Information


DRAVP ID  DRAVPe00714

Peptide Name   PE6

Sequence  PFVFLE

Sequence Length  6

UniProt ID  No entry found

Source  Synthetic construct(derived from the C-terminal sequence of α1-antitrypsin)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.22406118]HIV-1 IIIB:inhibition of virus replication(IC50>100 μM);inhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells(IC50>200 μM)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00714

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C39H54N6O9

Absent amino acids  ACDGHIKMNQRSTWY

Common amino acids  F

Mass  750.89

Pl  4

Basic residues  0

Acidic residues  1

Hydrophobic residues  4

Net charge  -1

Boman Index  811

Hydrophobicity  141.67

Aliphatic Index  113.33

Half Life 

  •     Mammalian:>20 hour
  •     Yeast:>20 hour
  •     E.coli:?

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity.

Pubmed ID   22406118

Reference   Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5. 

Author   Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K.

DOI   10.1016/j.bmcl.2012.02.037