General Information

General Information

DRAVP ID DRAVPe00716

Peptide Name PEM6

Sequence PEVFLM

Sequence Length 6

UniProt ID No entry found

Source Synthetic construct(derived from the C-terminal sequence of α1-antitrypsin)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.22406118]HIV-1 IIIB:inhibition of virus replication(IC50>100 μM);inhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells(IC50>200 μM)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00716

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C35H54N6O9S

Absent amino acids ACDGHIKNQRSTWY

Common amino acids EFLMPV

Mass 734.91

Pl 4

Basic residues 0

Acidic residues 1

Hydrophobic residues 3

Net charge -1

Boman Index 748

Hydrophobicity 126.67

Aliphatic Index 113.33

Half Life

Mammalian:>20 hour
Yeast:>20 hour
E.coli:?

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity.

Pubmed ID 22406118

Reference Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5.

Author Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K.

DOI 10.1016/j.bmcl.2012.02.037