DRAVP ID  DRAVPe00718

Peptide Name   CPM

Sequence  CPFVFLM

Sequence Length  7

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from the C-terminal sequence of α1-antitrypsin)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay 

Activity 

• [Ref.22406118]HIV-1 IIIB:inhibition of virus replication(IC50=8.96 ± 2.23 μM);inhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells between H9/HIV-1IIIB cells and MT-2 cells(IC50=67.20 ± 4.05 μM);
• HIV-1:inhibition of pseudovirus infection(IC50=5.95 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.22406118]MT-2 cells:CC50>200 μM.

Binding Target  Not found

Mechanism  The cyclic peptide inhibited HIV-1 infection by blocking virus fusion with and entry into the target cells.

PDB ID  None

Predicted Structure Download  DRAVPe00718

Linear/Cyclic  Cyclic

N-terminal Modification  Cyclization (N termini to C termini)

C-terminal Modification  Cyclization (N termini to C termini)

Other Modification  None

Stereochemistry  L

Literature 1

Title   Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity.

Pubmed ID   22406118

Reference   Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5. 

Author   Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K.

DOI   10.1016/j.bmcl.2012.02.037