General Information


DRAVP ID  DRAVPe00734

Peptide Name   T1989(FIV envelope protein (738-772))

Sequence  QTKDLQQKFYEIIMDIEQNNVQGKKGIQQLQKWED

Sequence Length  35

UniProt ID  P16090 

Source  Synthetic construct(derived from FIV envelope protein)



Activity Information


Target Organism  FIV

Assay  plaque-forming assay,RT infectivity assay

Activity 

  • [Ref.12186891]Feline immunodeficiency virus (FIV):inhibition of cell-cell fusion between FIV/CrFK cells and HeLa cells(EC50>2.321 μM,EC90>2.321 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00734

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C188H299N51O60S

Absent amino acids  ACHPRS

Common amino acids  Q

Mass  4265.81

Pl  5

Basic residues  5

Acidic residues  6

Hydrophobic residues  9

Net charge  -1

Boman Index  -9155

Hydrophobicity  -127.71

Aliphatic Index  75.14

Half Life 

  •     Mammalian:0.8 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  6990

Absorbance 280nm  205.59

Polar residues  6



Literature Information


Literature 1

Title   C-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. 

Pubmed ID   12186891

Reference   J Virol. 2002 Sep;76(18):9079-86.

Author   Medinas RJ, Lambert DM, Tompkins WA.

DOI   10.1128/jvi.76.18.9079-9086.2002