To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00744
Peptide Name YYS
Sequence YEEYSKKYEEYSKKYEEYSKKYEEYSKKYEEYSKKXX
Sequence Length 37
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism MERS-CoV
Assay MERS-CoV S Protein-Mediated Cell–Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide can interact with both MERS-CoV and IAV NHR trimeric coiled coils to prevent virus–cell membrane fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid).
Stereochemistry L
Physicochemical Information
Formula C215H303N45O69
Absent amino acids ACDFGHILMNPQRTVW
Common amino acids EKY
Mass 4880.72
Pl 6.48
Basic residues 10
Acidic residues 10
Hydrophobic residues 0
Net charge 0
Boman Index -14200
Hydrophobicity -245.95
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 14900
Absorbance 280nm 413.89
Polar residues 15
Literature Information
Literature 1
Title De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery.
Pubmed ID 30192544
Reference J Med Chem. 2018 Oct 11;61(19):8734-8745.
Author Wang C, Zhao L, Xia S, Zhang T, Cao R, Liang G, Li Y, Meng G, Wang W, Shi W, Zhong W, Jiang S, Liu K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.