DRAVP ID  DRAVPe00744

Peptide Name   YYS

Sequence  YEEYSKKYEEYSKKYEEYSKKYEEYSKKYEEYSKKXX

Sequence Length  37

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  MERS-CoV

Assay  MERS-CoV S Protein-Mediated Cell–Cell Fusion Assay

Activity 

• [Ref.30192544]MERS-CoV:inhibition of cell-cell fusion between 293T / MERS / EGPF cells and Huh-7 cells(EC50=6.26±2.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.30192544]Huh-7 cell:CC50=19.8±1.6 μM.

Binding Target  membrane

Mechanism  The peptide can interact with both MERS-CoV and IAV NHR trimeric coiled coils to prevent virus–cell membrane fusion.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  The 'X' at 36 indicates β-alanine,the 'X' at 37 indicates Lys-C16(palmitic acid).

Stereochemistry  L

Literature 1

Title   De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. 

Pubmed ID   30192544

Reference    J Med Chem. 2018 Oct 11;61(19):8734-8745.

Author   Wang C, Zhao L, Xia S, Zhang T, Cao R, Liang G, Li Y, Meng G, Wang W, Shi W, Zhong W, Jiang S, Liu K. 

DOI   10.1021/acs.jmedchem.8b00890